Our Research & Initiatives
Synthesis and functionalization of layered materials:
Our focus lies in synthesizing laterally size-controlled 2D single- or thin-layer molecular assemblies through chemical synthesis and processing, utilizing both top-down and bottom-up approaches. These assemblies are derived from precursors such as bulk materials, single molecular units, or single crystals. Presently, our research emphasizes graphene oxide, transition metal dichalcogenides (TMDs), and 2D organic frameworks. Additionally, we are actively engaged in pre- and post-synthetic surface modifications of these layered materials.
Molecular recognition:
The recognition of macromolecular surfaces using synthetic receptors offers promising applications in biomedical and biomaterial research, relying on noncovalent host-guest interactions. While macromolecule- and nanoparticle-based scaffolds show potential, their efficiency remains unclear. Layered nanostructures, with features like high surface-to-volume ratio, tunable functionality, and mechanical flexibility, provide a unique platform. Our group aims to harness these properties for surface recognition through specific and nonspecific functionalization.
Molecular sensing:
Molecular surface recognition enables diverse sensing applications in areas like diagnostics and environmental monitoring. Key factors like sensitivity and selectivity can be enhanced using layered nanostructures, which offer high surface areas and unique properties. We are developing optical and electronic sensors with these materials to detect targets such as bacteria, cancer cells, and pesticides.
Antimicrobial activity:
Layered materials exhibit strong antimicrobial activity due to sharp edge effects, terminal electron acceptors, and strong interactions with microbial membranes, disrupting their integrity. By modulating physical, electronic, and surface properties through different materials and functional ligands, we are investigating the cytotoxicity and antibacterial properties of chemically exfoliated and functionalized 2D materials.
Catalytic activity:
Beyond biological applications, an exciting breakthrough has emerged in nano-catalysis, which has seen rapid growth in both homogeneous and heterogeneous catalysis. However, the use of 2D nanomaterials as catalysts in organic synthesis remains limited. Using graphene oxide (GO) as a carbocatalyst, we developed an efficient, aqueous protocol for the Diels-Alder reaction at room temperature, achieving high yields, broad substrate scope, and exceptional functional group tolerance.
Additionally, we demonstrated the photocatalytic activity of 2D MoS₂ in synthesizing Schiff bases by oxidizing primary aromatic amines to imines with good yields and selectivity—marking the first application of 2D MoS₂ in organic transformations. We are currently expanding these methodologies to other synthetic applications.
Lipid Nanoparticles:
In our lab, we are pioneering the development of next-generation lipid nanoparticles for breakthrough drug delivery solutions. By synthesizing custom-designed lipids with unique headgroups, linkers, and tail modifications, we are unlocking the potential to fine-tune these nanoparticles for maximum efficiency and precision. Our approach to exploring the structure-activity relationships (SAR) of these lipids allows us to create smarter, more targeted drug delivery systems that enhance therapeutic outcomes, from stabilizing mRNA-based treatments to improving precision medicine. Join us as we push the boundaries of innovation to revolutionize healthcare.
